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September 1, 2002Journal of Biological ChemistryOpen Access

Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro

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Authors

MMMarion MacFarlaneMRC Laboratory of Molecular BiologyWMWendy MerrisonUniversity of LeicesterSBShawn B. BrattonThe University of Texas MD Anderson Cancer Center

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MacFarlane et al. (2002) studied this question.

synapsesocial.com/papers/6a77bfc02e130d02afecc1c3https://doi.org/10.1074/jbc.m200317200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Inhibitor of Apoptosis Protein-Binding Domain of Smac Is Not Essential for Its Proapoptotic Activity2001 · 103 citations
  2. 2Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL1997 · 566 citations
  3. 3Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked1997 · 4,961 citations
  4. 4RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination1999 · 1,164 citations
  5. 5The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif2002 · 544 citations