Why the study?
Does tonin cleave human angiotensinogen to form angiotensin II?
Population
In vitro model using partially purified human angiotensinogen from outdated human blood bank plasma
Comparison
Cleavage by tonin vs Cleavage by renin
Design
Preclinical
Authors
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May support an alternative angiotensin II pathway in models; leaves open relevance to human cardiovascular disease.
Does tonin cleave human angiotensinogen to form angiotensin II?
Tonin can directly cleave human angiotensinogen to generate angiotensin II, providing a potential alternative biochemical pathway for angiotensin II formation.
Grisé et al. (1981) studied this question.
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