What question did this study set out to answer?

To determine the relationship between blood pressure and performance across multiple cognitive domains in older adults without clinical stroke or dementia.

July 9, 2013Archives of Clinical NeuropsychologyOpen Access

Blood Pressure and Cognition Among Older Adults: A Meta-Analysis

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Why the study?

Does blood pressure correlate with cognitive performance in older adults free of clinical stroke and dementia?

Population

12 studies pooling 4,076 older adults (age range 43-91 years) free of clinical stroke and dementia.

Design

Meta-analysis

Authors

KGKarolina GiffordUniversity of Central Florida MBMaria BadaraccoBoston University DLD. LiuHarbin University of Science and Technology

Discussion

Member takes

Implication

May support BP monitoring to help preserve cognition in older adults; extends meta-analytic evidence for these associations.

Key Points

To determine the relationship between blood pressure and performance across multiple cognitive domains in older adults without clinical stroke or dementia.
Conducted a systematic search across PubMed and PsycINFO databases, identifying 230 relevant studies.
Synthesized data across 12 eligible articles comprising 4,076 participants aged 43 to 91 years, with a sub-analysis of 8 studies (n = 2,141) controlling for vascular covariates.
Across all included cohorts, blood pressure significantly correlated with poorer episodic memory (r = -0.18, p < .001) and worse global cognition (r = -0.07, p < .001).
In studies adjusting for vascular covariates, blood pressure remained negatively associated with global cognition (r = -0.11, p < .001) and episodic memory (r = -0.20, p < .001), positively related to attention (r = 0.14, p = .002), and trended toward lower language scores (r = -0.22, p = .07).

Structured PICO

Does blood pressure correlate with cognitive performance in older adults free of clinical stroke and dementia?

Population

12 studies pooling 4,076 older adults (age range 43-91 years) free of clinical stroke and dementia.

Intervention

Blood pressure levels

Outcome

Correlation between blood pressure and multiple cognitive domains (episodic memory, global cognition, attention, language)

Higher blood pressure is modestly associated with worse episodic memory and global cognition in older adults without dementia, highlighting the importance of blood pressure management in preventing cognitive decline.

Cite This Study

Gifford et al. (2013) studied this question.

synapsesocial.com/papers/6a77c1c92e130d02afecc312 https://doi.org/10.1093/arclin/act046

Topics

Hypertension management

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Blood Pressure and Cognition Among Older Adults: A Meta-Analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Blood Pressure and Cognition Among Older Adults: A Meta-Analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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