ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity

This is the authors' abstract. We don't add key points for this paper.

In a recent study published in Cancer Cell , Liao et al. 1 identified CD8 + T-cell-derived interferon (IFN)γ in combination with polyunsaturated fatty acids (PUFAs) as a natural ferroptosis inducer (FIN) to trigger tumor ferroptosis and promote anti-tumor immunity in an acyl-coenzyme A synthetase long-chain family member 4 (ACSL4)-dependent manner.