September 1, 1996Hypertension

Thromboxane A2Mediates the Stimulation of Inositol 1,4,5-Trisphosphate Production and Intracellular Calcium Mobilization by Bradykinin in Neonatal Rat Ventricular Cardiomyocytes

View Full Paper

Ask AI

Bookmark

Population

Neonatal rat ventricular cardiomyocytes in primary culture

Comparison

Bradykinin and various pharmacological modulators vs Control cultures (unstimulated)

Design

Preclinical

Authors

FNFumiaki NakamuraWaseda University RMRichard D. MinshallUniversity of Illinois Chicago GBGuy C. Le BretonUniversity of Illinois Chicago

Discussion

Member takes

Implication

Suggests thromboxane A2 mediates bradykinin effects in cardiomyocytes; leaves open relevance to human hypertension.

Structured PICO

Population

Neonatal rat ventricular cardiomyocytes in primary culture

Intervention

Bradykinin (1 mu/L) and various pharmacological modulators (indomethacin, dexamethasone, U73122, BM 13177, U46619, phorbol 12-myristate 13-acetate, cholera/pertussis toxin)

Comparator

Control cultures (unstimulated)

Outcome

Inositol 1,4,5-trisphosphate (IP3) production and intracellular calcium mobilizationsurrogate

Bradykinin enhances IP3 production and calcium mobilization in cardiomyocytes primarily via phospholipase A2 stimulation and subsequent thromboxane A2 formation.

Cite This Study

Nakamura et al. (1996) studied this question.

synapsesocial.com/papers/6a77c27d137c7dcc81be0bda https://doi.org/10.1161/01.hyp.28.3.444

View Full Paper

Ask AI

Bookmark

Thromboxane A2Mediates the Stimulation of Inositol 1,4,5-Trisphosphate Production and Intracellular Calcium Mobilization by Bradykinin in Neonatal Rat Ventricular Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thromboxane A2Mediates the Stimulation of Inositol 1,4,5-Trisphosphate Production and Intracellular Calcium Mobilization by Bradykinin in Neonatal Rat Ventricular Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider