Why the study?
Because SPRINT excluded patients with prior stroke, the ideal blood pressure target for secondary stroke prevention remains unknown.
Does intensive blood pressure control reduce stroke recurrence in patients with a history of stroke?
Population
1280 patients with a history of stroke within the previous 3 years in Japan
Comparison
Intensive BP control (<120/80 mm Hg) vs standard BP control (<140/90 mm Hg)
Design
Multicenter randomized clinical trial
Follow-up
Mean 3.9 years
Authors
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Supports <130/80 mm Hg target for secondary stroke prevention; extends SPRINT findings to post-stroke patients via meta-analysis.
Does intensive blood pressure control reduce stroke recurrence in patients with a history of stroke?
While the individual trial was stopped early and showed a non-significant trend, an updated meta-analysis supports intensive blood pressure lowering for secondary stroke prevention.
Kitagawa et al. (2019) studied this question.
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