Why the study?
Elevated blood pressure is a major modifiable risk factor for cardiovascular morbidity and mortality, but the optimal systolic blood pressure target in hypertensive patients remains unclear.
Does intensive systolic blood pressure control (≤120 mmHg) reduce cardiovascular events in hypertensive patients compared to standard control (≤140 mmHg)?
Population
39 811 hypertensive patients across six RCTs
Comparison
Intensive systolic BP control (≤120 mmHg) vs standard systolic BP control (≤140 mmHg)
Design
Meta-analysis of randomized controlled trials
Authors
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Supports intensive SBP targets in hypertension; confirms benefits across six RCTs with 39,811 patients.
Does intensive systolic blood pressure control (≤120 mmHg) reduce cardiovascular events in hypertensive patients compared to standard control (≤140 mmHg)?
Intensive systolic blood pressure control to ≤120 mmHg significantly reduces cardiovascular morbidity and mortality in hypertensive patients, though it is associated with an increased risk of syncope.
Prizão et al. (2025) studied this question.