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December 29, 2015Cardiovascular ResearchOpen Access

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection

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Population

Rat heart tissue, Kv7.4-transfected cells, H9c2 cardiomyoblasts, freshly isolated adult cardiomyocytes…

Comparison

Kv7 activators vs Untreated controls, Kv7 blocker XE991, or RNA…

Design

Preclinical

Authors

LTLara TestaiUniversity of PisaVBVincenzo BarreseFederico II University HospitalMSMaria Virginia SoldovieriUniversity of Molise

Discussion

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Implication

Kv7.4 channels may confer ischemic cardioprotection in rodents; leaves open therapeutic targeting in human hearts.

Structured PICO

P
Population
Rat heart tissue, Kv7.4-transfected cells, H9c2 cardiomyoblasts, freshly isolated adult cardiomyocytes, isolated cardiac mitochondria, and Langendorff-perfused rat hearts
I
Intervention
Kv7 activators (retigabine 1-30 µM and flupirtine 30 µM)
C
Comparator
Untreated controls, Kv7 blocker XE991, or RNA interference reducing Kv7.4 expression
O
Outcome
Cellular damage in H9c2 cells exposed to anoxia/re-oxygenation and functional/morphological changes triggered by global ischaemia/reperfusion in Langendorff-perfused rat heartssurrogate

Kv7.4 channels are present in cardiac mitochondria and their activation by retigabine exerts a cardioprotective effect against ischaemia/reperfusion injury in preclinical models.

Cite This Study

Testai et al. (2015) studied this question.

synapsesocial.com/papers/6a77dd32576efb0ddaf7b13fhttps://doi.org/10.1093/cvr/cvv281
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