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June 24, 2005The Journal of PhysiologyOpen Access

Endothermic force generation, temperature‐jump experiments and effects of increased MgADP in rabbit psoas muscle fibres

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Population

Maximally Ca2+-activated, permeabilized, single fibres from rabbit psoas muscle

Comparison

Rapid laser temperature-jump and increased [MgADP] vs Baseline conditions

Design

Preclinical

Authors

MCM. E. CouplandGPGavin J. PinnigerKRK. W. Ranatunga

Discussion

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Overview

Should not yet change practice; extends cross-bridge kinetic models in skeletal muscle while leaving cardiac relevance open.

Structured PICO

P
Population
Maximally Ca2+-activated, permeabilized, single fibres from rabbit psoas muscle (length approximately 2 mm; sarcomere length, 2.5 microm)
I
Intervention
Rapid laser temperature-jump (approximately 3 degrees C) and increased [MgADP] (up to 4 mM)
C
Comparator
Baseline conditions (lower [MgADP], different temperatures)
O
Outcome
Tension rise (endothermic force) and shortening velocity

Increased MgADP slows the temperature-jump-induced tension rise and increases tension in rabbit psoas muscle fibers, which can be simulated by a five-step kinetic model.

Cite This Study

Coupland et al. (2005) studied this question.

synapsesocial.com/papers/6a77e810576efb0ddaf7baa1https://doi.org/10.1113/jphysiol.2005.090084
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