Key result
Laser temperature-jump experiments in skinned rabbit psoas fibers revealed a three-step mechanism of contraction involving temperature-sensitive and temperature-insensitive steps.
Population
Maximally Ca(2+)-activated, skinned rabbit psoas fibers
Comparison
Laser temperature-jump experiments over a… vs Length-jump Huxley-Simmons phases
Design
Preclinical
Authors
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May refine biophysical models of force generation; leaves open translation to human cardiac or skeletal muscle.
This basic science study elucidates the kinetics of muscle tension generation, proposing a three-step mechanism involving an order-disorder transition.
Davis et al. (1995) studied this question. Laser temperature-jump vs. Length-jump Huxley-Simmons phases was evaluated on Tension rise kinetics. Laser temperature-jump experiments in skinned rabbit psoas fibers revealed a three-step mechanism of contraction involving temperature-sensitive and temperature-insensitive steps.
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