Key result
Temperature jumps reveal Huxley-Simmons phase 2 tension generation features a fast ~950 s-1 endothermic component.
Population
Skinned rabbit psoas muscle fibers and frog fibers
Design
Preclinical
Authors
Loading...
Cautions against clinical extrapolation from skeletal fibers; extends cross-bridge kinetic models in striated muscle.
Tension generation in muscle fibers during the Huxley-Simmons phase 2 occurs in a single endothermic, entropy-driven step.
Davis et al. (1993) studied Skinned rabbit psoas and frog muscle fibers. Laser temperature-jump and length-jump was evaluated on Tension generation in the time domain of the Huxley-Simmons phase 2. Tension generation in the Huxley-Simmons phase 2 occurs in a single endothermic step, characterized by a fast kinetic component (rate constant 950 s-1 at 1°C) and a slow temperature-dependent component.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: