June 1, 2001Coronary Artery Disease

Time course of vascular remodeling, formation of neointima and formation of neoadventitia after angioplasty in a porcine model

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Population

Porcine model (pigs), n=5 per follow-up group (total n=35)

Design

Preclinical

Follow-up

Up to 56 days

Authors

MMMichael MængInterventional Cardiology POPeter G. OlesenAalborg University Hospital NENiels C. EmmertsenAarhus University Hospital

Discussion

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Implication

Adventitia may modulate post-angioplasty restenosis; leaves open whether targeting it alters human outcomes.

Structured PICO

Population

Porcine model (pigs), n=5 per follow-up group (total n=35)

Intervention

Deep vessel-wall injury induced by conventional balloon angioplasty (circumflex and right coronary arteries) and retraction of a chain-encircled balloon (left anterior descending artery)

Outcome

Time courses of vascular remodeling, formation of neointima, and adventitial changes measured by angiography, IVUS, and histomorphometrysurrogate

In a porcine model, neoadventitia formation occurs early after angioplasty and precedes constrictive remodeling and neointima formation, highlighting the adventitia's role in restenosis.

Cite This Study

Mæng et al. (2001) studied this question.

synapsesocial.com/papers/6a77ec4edf493903fd1f5340 https://doi.org/10.1097/00019501-200106000-00004

Topics

Coronary artery disease Coronary CT angiography

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Time course of vascular remodeling, formation of neointima and formation of neoadventitia after angioplasty in a porcine model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Time course of vascular remodeling, formation of neointima and formation of neoadventitia after angioplasty in a porcine model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider