Key result
Balloon angioplasty in a rabbit model caused early endothelial denudation, with cellular proliferation peaking at day 7 to 14 and maximal intimal thickening at 1 month.
A rabbit model of iliac artery balloon angioplasty demonstrates reproducible myointimal hyperplasia peaking at 1 month, providing a useful model for assessing inhibitory agents.
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Rabbit iliac angioplasty model offers reproducible hyperplasia timeline; leaves open translation to human restenosis therapies.
A detailed temporal sequence of vessel wall changes in a rabbit model of balloon angioplasty, to the iliac arteries, at 30 min, 2 h, day 1, day 3, day 7, day 14, 1 month, and 3 months was established using light microscopy, immunostaining for proliferating cell nuclear antigen, and electron microscopy. Complete endothelial denudation with extensive platelet and fibrin deposition was evident early. Intimal thickening, characterized by myointimal hyperplasia, was observed at day 7 and reached a maximum at 1 month. Re-endothelization was complete by day 14. Cellular proliferation, seen early at day 1, reached a maximum at day 7 for the media and day 14 for the intima before returning to baseline levels by 1 month. This simple model of angioplasty with its reproducible myointimal hyperplasia should prove useful for assessing any potential agents for inhibiting this process.
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More et al. (1994) studied Balloon angioplasty. Balloon angioplasty was evaluated on Temporal sequence of vessel wall changes. Balloon angioplasty in a rabbit model caused early endothelial denudation, with cellular proliferation peaking at day 7 to 14 and maximal intimal thickening at 1 month.
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