Population
rabbit model of balloon angioplasty to the iliac arteries
Design
Preclinical
Follow-up
3 months
Key result
Balloon angioplasty in a rabbit model caused early endothelial denudation, with cellular proliferation peaking at day 7 to 14 and maximal intimal thickening at 1 month.
Authors
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Rabbit iliac angioplasty model offers reproducible hyperplasia timeline; leaves open translation to human restenosis therapies.
A rabbit model of iliac artery balloon angioplasty demonstrates reproducible myointimal hyperplasia peaking at 1 month, providing a useful model for assessing inhibitory agents.
More et al. (1994) studied Balloon angioplasty. Balloon angioplasty was evaluated on Temporal sequence of vessel wall changes. Balloon angioplasty in a rabbit model caused early endothelial denudation, with cellular proliferation peaking at day 7 to 14 and maximal intimal thickening at 1 month.