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May 1, 1994European Heart Journal

The percentage of macrophages in the intimal layer significantly increased at 14 days after angioplasty (9.1 ± 4.3% vs 2.0 ± 1.7% in control, P<0.01) and persisted up to 21 days (8.0 ± 3.3% vs 3.1 ± 0.8% in sham, P<0.05).

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Why the study?

Does transluminal balloon angioplasty increase macrophage accumulation in the intimal layer in a rabbit model of atheroma?

Population

45 male New Zealand White rabbits with an intimal atheroma produced by repeated weak electrical stimulation…

Comparison

Transluminal balloon angioplasty. vs Control group without balloon treatment.

Design

Preclinical

Follow-up

up to 42 days

Authors

HHHartmut HankeSHStefan HassensteinAUAnja Ulmer

Discussion

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Overview

Macrophage accumulation may contribute to restenosis after angioplasty; hypothesis-generating in rabbits and leaves open human relevance.

Structured PICO

Does transluminal balloon angioplasty increase macrophage accumulation in the intimal layer in a rabbit model of atheroma?

P
Population
45 male New Zealand White rabbits with an intimal atheroma produced by repeated weak electrical stimulation of the right carotid artery and an 0.5% cholesterol diet for 28 days.
I
Intervention
Transluminal balloon angioplasty.
C
Comparator
Control group without balloon treatment (sham group, killed after 21 days).
O
Outcome
Time course of the accumulation of macrophages in the intimal layer and intimal thickening, measured using immunocytochemical techniques.surrogate

Macrophage accumulation in the arterial wall is a delayed phenomenon following balloon angioplasty, peaking between 14 and 21 days post-injury, which may contribute to the vascular response to injury and restenosis.

Cite This Study

Hanke et al. (1994) studied this question.

synapsesocial.com/papers/6a7fb4f6fcb7d43d28406be3https://doi.org/10.1093/oxfordjournals.eurheartj.a060569
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Macrophage on Neointimal Formation after Balloon or Stent Injury in Hypercholesterolemic Rabbits2005 · 1 citations
  2. 2Adventitial Angiogenesis Early After Coronary Angioplasty1999 · 52 citations
  3. 3A time sequence of vessel wall changes in an experimental model of angioplasty1994 · 46 citations
  4. 4Time Course of Cellular Proliferation, Intimal Hyperplasia, and Remodeling Following Angioplasty in Monkeys With Established Atherosclerosis1996 · 106 citations
  5. 5Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery.1991 · 73 citations