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January 1, 2001Japanese Circulation Journal-english EditionOpen Access

Effect of Hypercholesterolemia on Macrophage Infiltration After Balloon Injury to Rabbit Iliac Artery

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Why the study?

Does hypercholesterolemia increase macrophage infiltration after balloon injury in rabbit iliac arteries?

Population

Rabbit iliac arteries subjected to balloon injury

Comparison

Hypercholesterolemia vs Normocholesterolemia

Design

Preclinical

Follow-up

Up to 14 days

Authors

JSJong‐Min SongHKHyo‐Soo KimSPSun Jung Park

Discussion

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Overview

Supports hypercholesterolemia-driven post-injury inflammation in rabbits; leaves open relevance to human restenosis or therapy.

Structured PICO

Does hypercholesterolemia increase macrophage infiltration after balloon injury in rabbit iliac arteries?

P
Population
Rabbit iliac arteries subjected to balloon injury
I
Intervention
Hypercholesterolemia
C
Comparator
Normocholesterolemia
O
Outcome
Macrophage infiltration, ICAM-1 and VCAM-1 expression, and NF-kappaB activation evaluated at 2h, 1 day, 3 days, 7 days, and 14 days after balloon injurysurrogate

In vivo hypercholesterolemia enhances macrophage infiltration following vascular injury via increased NF-kappaB activation and ICAM-1 expression.

Cite This Study

Song et al. (2001) studied this question.

synapsesocial.com/papers/6a75b92772aedb66d66a3c15https://doi.org/10.1253/jcj.65.117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery.1991 · 73 citations
  2. 2The Effects of Macrophage on Neointimal Formation after Balloon or Stent Injury in Hypercholesterolemic Rabbits2005 · 1 citations
  3. 3Accumulation of macrophages in the arterial vessel wall following experimental balloon angioplasty1994 · 52 citations
  4. 4Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty2002 · 27 citations
  5. 5Effect of Hypercholesterolemia on Myocardial Necrosis and Apoptosis in the Setting of Ischemia-Reperfusion2009 · 85 citations