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September 14, 2009Circulation

Infarct size was significantly greater in hypercholesterolemic versus normocholesterolemic pigs (61% versus 42%, P<0.05).

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Why the study?

Does dietary-induced hypercholesterolemia increase myocardial necrosis and apoptosis in the setting of acute ischemia-reperfusion injury in a porcine model?

Population

14 Yucatan male pigs (n=7 normocholesterolemic, n=7 hypercholesterolemic)

Comparison

Dietary-induced hypercholesterolemia subjected… vs Normocholesterolemic diet subjected to the same…

Design

Preclinical

Follow-up

120 minutes of reperfusion

Authors

RORobert M. OsipovCBCesario BianchiJFJun Feng

Discussion

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Member takes

Overview

Hypercholesterolemia may enlarge infarcts in reperfusion; leaves open translation to human acute coronary syndromes.

Structured PICO

Does dietary-induced hypercholesterolemia increase myocardial necrosis and apoptosis in the setting of acute ischemia-reperfusion injury in a porcine model?

P
Population
14 Yucatan male pigs (n=7 normocholesterolemic, n=7 hypercholesterolemic)
I
Intervention
Dietary-induced hypercholesterolemia subjected to 60 minutes of left anterior descending coronary artery occlusion followed by 120 minutes of reperfusion
C
Comparator
Normocholesterolemic diet subjected to the same ischemia-reperfusion protocol
O
Outcome
Infarct size (necrosis assessed by TTC staining)surrogate

Experimental hypercholesterolemia exacerbates myocardial necrosis, oxidative stress, and apoptosis during acute ischemia-reperfusion injury in a porcine model.

Cite This Study

Osipov et al. (2009) studied this question.

synapsesocial.com/papers/6a8a6d9a2e8050e6742e5698https://doi.org/10.1161/circulationaha.108.842724
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