April 1, 2002Lipids

Increased cardiomyocyte apoptosis following ischemia and reperfusion in diet‐induced hypercholesterolemia: Relation to Bcl‐2 and bax proteins and caspase‐3 activity

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Structured PICO

Population

28 male New Zealand white rabbits

Intervention

Chow supplemented with 10% cholesterol for 8 weeks, followed by 30 min of left circumflex artery occlusion and 4 h of reperfusion

Comparator

Standard chow for 8 weeks, followed by 30 min of left circumflex artery occlusion and 4 h of reperfusion

Outcome

Infarct size (% of risk region) and percentage of TUNEL-positive cardiomyocytes in the ischemic nonnecrotic myocardiumsurrogate

Hypercholesterolemia exacerbates cardiac reperfusion injury by increasing both infarct size and the extent of cardiomyocyte apoptosis.

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Hypercholesterolemia may worsen reperfusion injury in rabbits; hypothesis-generating for human MI and requires clinical validation.

Wang et al. (2002) studied this question.

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