Key result
Cholesterol diet-induced hypercholesterolemia significantly prolonged embolization duration in rabbit arterioles compared to normal chow (>600 vs 142 seconds, P<0.0001), but not in venules.
Population
Nonatherosclerotic rabbit mesenteric arterioles and venules (diameter 21 to 45 micrometer)
Comparison
Cholesterol diet-induced hypercholesterolemia… vs Normal chow-fed (NC) control group
Design
Preclinical
Authors
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Should not yet change clinical practice; hypothesis-generating for hypercholesterolemia's selective arteriolar effects on embolization.
Absolute Event Rate: 600% vs 142%
p-value: p=<0.0001
Hypercholesterolemia selectively enhances thromboembolism in arterioles but not venules, an effect that can be reversed by stimulating endogenous NO production.
Broeders et al. (2002) studied Hypercholesterolemia. Cholesterol diet-induced hypercholesterolemia vs. Normal chow-fed control group was evaluated on Embolization duration in arterioles (p=<0.0001). Cholesterol diet-induced hypercholesterolemia significantly prolonged embolization duration in rabbit arterioles compared to normal chow (>600 vs 142 seconds, P<0.0001), but not in venules.
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