Why the study?
Does cholesterol reduction reverse cavernosal smooth muscle dysfunction in hypercholesterolemic rabbits?
Population
Rabbits (preclinical model of hypercholesterolemia)
Comparison
1% cholesterol diet for 4 weeks followed by a… vs 1% cholesterol diet (hypercholesterolemia)
Design
Preclinical
Follow-up
8 weeks
Authors
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Cholesterol reduction should not yet alter ED management; leaves open reversibility in humans and requires clinical trials.
Does cholesterol reduction reverse cavernosal smooth muscle dysfunction in hypercholesterolemic rabbits?
Cholesterol reduction reverses cavernosal smooth muscle dysfunction and normalizes relaxation in a rabbit model of hypercholesterolemia.
Kim et al. (1994) studied this question.
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