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January 1, 2005Sunhwan'gi

The Effects of Macrophage on Neointimal Formation after Balloon or Stent Injury in Hypercholesterolemic Rabbits

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Why the study?

Does stent injury compared to balloon injury alter macrophage-mediated neointimal formation in hypercholesterolemic rabbits?

Population

Male New Zealand White rabbits fed with a 1% cholesterol diet for 2 weeks

Comparison

Stenting to one iliac artery (stent injury, SI) vs Balloon dilatation to the contralateral iliac…

Design

Preclinical

Follow-up

28 days

Authors

MRMoo‐Yong RheeYKYoung Kwon KimMLMyoung Yong Lee

Discussion

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Overview

Stent injury may drive greater neointimal hyperplasia via distinct macrophage patterns in rabbits; hypothesis-generating and should not change clinical practice.

Structured PICO

Does stent injury compared to balloon injury alter macrophage-mediated neointimal formation in hypercholesterolemic rabbits?

P
Population
Male New Zealand White rabbits fed with a 1% cholesterol diet for 2 weeks
I
Intervention
Stenting to one iliac artery (stent injury, SI)
C
Comparator
Balloon dilatation to the contralateral iliac artery (balloon injury, BI)
O
Outcome
Neointimal formation (sizes and cell numbers) and macrophage numbers at 7, 14, and 28 dayssurrogate

Mechanical arterial injury induces AGE formation and RAGE overexpression in macrophages, with differing macrophage effects on neointima formation between balloon and stent injuries.

Cite This Study

Rhee et al. (2005) studied this question.

synapsesocial.com/papers/6a79d07274c579e25f890cd4https://doi.org/10.4070/kcj.2005.35.11.801
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