Population
21 cynomolgus monkeys fed an atherogenic diet for 36 months to establish atherosclerosis
Comparison
Angioplasty performed in the left iliac artery vs Uninjured iliac arteries within each animal
Design
Preclinical
Follow-up
up to 28 days
Key result
Angioplasty in atherosclerotic monkeys caused transient lumen enlargement followed by increased cellular proliferation at 4-7 days and marked intimal thickening by 14-28 days.
Authors
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Atherosclerotic primate angioplasty model may guide restenosis research; leaves open direct translation to human clinical outcomes.
This atherosclerotic primate model demonstrates that plaque fracture, delayed recoil, intimal hyperplasia, and remodeling closely resemble the human response to angioplasty, providing a valuable model for studying restenosis.
Geary et al. (1996) studied Atherosclerosis (n=21). Angioplasty vs. Uninjured iliac arteries within each animal was evaluated on Cellular proliferation, intimal hyperplasia, and remodeling. Angioplasty in atherosclerotic monkeys caused transient lumen enlargement followed by increased cellular proliferation at 4-7 days and marked intimal thickening by 14-28 days.