What question did this study set out to answer?

To characterize circulating levels of renin, renin-substrate, angiotensin II, and aldosterone during human pregnancy and the menstrual cycle, and to explore their underlying physiological mechanisms.

March 1, 1971Scottish Medical Journal

Renin, Angiotensin and Aldosterone in Human Pregnancy and the Menstrual Cycle

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Authors

JRJ. I. S. RobertsonWestern Infirmary RWR. J. WeirUniversity of Utah GDG. DüsterdieckMunich University of Applied Sciences

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Implication

Observational analysis reveals elevated renin-angiotensin-aldosterone activity across pregnancy and the luteal phase, suggesting a compensatory response to maternal sodium depletion.

Key Points

To characterize circulating levels of renin, renin-substrate, angiotensin II, and aldosterone during human pregnancy and the menstrual cycle, and to explore their underlying physiological mechanisms.
Measured plasma concentrations of renin, renin-substrate, angiotensin II, and aldosterone secretion across pregnancy stages and during the menstrual cycle.
Assessed hormonal responses to dietary sodium alterations and examined non-renal renin synthesis in human chorionic tissue.
Plasma renin-substrate is consistently raised in pregnancy, driving a significant positive correlation between maternal plasma aldosterone and the product of concurrent renin and renin-substrate levels.
Plasma aldosterone, renin, and angiotensin II levels increase above non-pregnant ranges as early as week 16 and in the menstrual luteal phase, whereas values are slightly lower in pre-eclampsia than in normal pregnancy.

Cite This Study

Robertson et al. (1971) studied this question.

synapsesocial.com/papers/6a77f309a0847c3df1ecafe2 https://doi.org/10.1177/003693307101600303

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Implication

Observational analysis reveals elevated renin-angiotensin-aldosterone activity across pregnancy and the luteal phase, suggesting a compensatory response to maternal sodium depletion.

Renin, Angiotensin and Aldosterone in Human Pregnancy and the Menstrual Cycle

Discussion

Member takes

Implication

Key Points

Cite This Study

Renin, Angiotensin and Aldosterone in Human Pregnancy and the Menstrual Cycle

Discussion

Member takes

Implication

Key Points

Cite This Study

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