Deep brain stimulation of the anterior thalamic nucleus in Lennox–Gastaut syndrome with EEG changes during off–on stimulation

Deep brain stimulation of the thalamus has demonstrated possible therapeutic value in Lennox–Gastaut syndrome (LGS), especially when directed at the centromedian nucleus, although reported outcomes remain inconsistent [1–3]. In earlier work, we described significant clinical improvement in three patients treated with stimulation of the anterior nucleus (ANT) [4]. In the present report, we detail the electroclinical modifications observed in one adult patient during periods when stimulation was turned off and then on.