What question did this study set out to answer?

To evaluate the safety and clinical efficacy of bilateral electrical stimulation of the anterior nuclei of the thalamus for treating medically refractory partial epilepsy.

March 20, 2010Epilepsia

Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy

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Authors

RFRobert S. FisherGates (United States)VSVicenta SalanovaIndiana University Health TWThomas C. WittNeurological Surgery

Discussion

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Overview

Randomized double-blind trial demonstrates significant seizure frequency reduction in adults with medically refractory partial epilepsy, indicating the therapeutic utility of thalamic stimulation.

Key Points

To evaluate the safety and clinical efficacy of bilateral electrical stimulation of the anterior nuclei of the thalamus for treating medically refractory partial epilepsy.
Multicenter, double-blind randomized clinical trial of 110 adults with medically refractory partial seizures, including secondarily generalized seizures.
Participants were randomized to receive bilateral thalamic stimulation or sham stimulation during a 3-month blinded phase, followed by an unblinded active stimulation phase with follow-up extending to 2 years.
During the final month of the blinded phase, the stimulated group had a 29% greater reduction in seizure frequency compared to controls (generalized estimating equations model, p = 0.002), with unadjusted median reductions of 40.4% versus 14.5%.
After 2 years of active stimulation, median seizure frequency decreased by 56%, 54% of participants experienced at least a 50% seizure reduction, and 14 participants achieved seizure freedom for at least 6 months.
No symptomatic hemorrhages or brain infections were observed, although participants in the stimulated group reported higher frequencies of depression and memory problems as adverse events.

Cite This Study

Fisher et al. (2010) studied this question.

synapsesocial.com/papers/6a825cd6c7a413f7f12a4fa5 https://doi.org/10.1111/j.1528-1167.2010.02536.x

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March 20, 2010Epilepsia

Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy

View Full Paper

Ask AI

Bookmark

Authors

RFRobert S. FisherGates (United States)VSVicenta SalanovaIndiana University Health TWThomas C. WittNeurological Surgery

Discussion

Member takes

Overview

Randomized double-blind trial demonstrates significant seizure frequency reduction in adults with medically refractory partial epilepsy, indicating the therapeutic utility of thalamic stimulation.

Key Points

To evaluate the safety and clinical efficacy of bilateral electrical stimulation of the anterior nuclei of the thalamus for treating medically refractory partial epilepsy.
Multicenter, double-blind randomized clinical trial of 110 adults with medically refractory partial seizures, including secondarily generalized seizures.
Participants were randomized to receive bilateral thalamic stimulation or sham stimulation during a 3-month blinded phase, followed by an unblinded active stimulation phase with follow-up extending to 2 years.
During the final month of the blinded phase, the stimulated group had a 29% greater reduction in seizure frequency compared to controls (generalized estimating equations model, p = 0.002), with unadjusted median reductions of 40.4% versus 14.5%.
After 2 years of active stimulation, median seizure frequency decreased by 56%, 54% of participants experienced at least a 50% seizure reduction, and 14 participants achieved seizure freedom for at least 6 months.
No symptomatic hemorrhages or brain infections were observed, although participants in the stimulated group reported higher frequencies of depression and memory problems as adverse events.

Cite This Study

Fisher et al. (2010) studied this question.

synapsesocial.com/papers/6a825cd6c7a413f7f12a4fa5 https://doi.org/10.1111/j.1528-1167.2010.02536.x

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