Why the study?
Do functional MC4R mutations reduce sympathetic nerve traffic and blood pressure in obese humans?
Population
8 heterozygous carriers of MC4R mutations leading to reduced function and control subjects matched for…
Comparison
Heterozygous MC4R mutation carrier status vs Control subjects matched for gender, age, and…
Design
Case-control
Authors
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MC4R mutations associate with blunted sympathetic responses in obese humans; extends mechanistic insights but remains hypothesis-generating and should not change practice.
Do functional MC4R mutations reduce sympathetic nerve traffic and blood pressure in obese humans?
Functional MC4R mutations are associated with reduced sympathetic nerve activity, providing a mechanistic explanation for the lack of hypertension in this specific obesity phenotype.
Sayk et al. (2010) studied this question.
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