Why the study?
Does nonrheumatic atrial fibrillation increase the frequency of brain infarction in elderly patients not on anticoagulant therapy?
Population
367 autopsy specimens from elderly patients, including 136 consecutive patients with nonrheumatic atrial…
Comparison
Nonrheumatic atrial fibrillation (NRAF) (Exposure) vs Age-matched control subjects without NRAF
Design
Cohort
Authors
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NRAF was associated with more symptomatic infarctions in elderly patients; extends autopsy observations but leaves open randomized trials on anticoagulation.
Does nonrheumatic atrial fibrillation increase the frequency of brain infarction in elderly patients not on anticoagulant therapy?
Autopsy data confirms that elderly patients with nonrheumatic atrial fibrillation have a significantly higher burden of symptomatic and asymptomatic cardioembolic brain infarctions compared to controls.
Yamanouchi et al. (1997) studied this question.
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