Why the study?
Are changes in DNA methylation of leukocytes associated with the pathogenesis of essential hypertension in young African American males?
Population
182 young African American males across three cohorts: a discovery cohort, a first validation cohort, and a…
Design
Case-control
Authors
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Leukocyte methylation changes may link epigenetics to early hypertension in young African American males; hypothesis-generating and requires replication before clinical relevance.
Are changes in DNA methylation of leukocytes associated with the pathogenesis of essential hypertension in young African American males?
DNA methylation changes in leukocytes, specifically in the SULF1 gene, are associated with essential hypertension in young African American males, with the effect appearing to be age-dependent.
Wang et al. (2013) studied this question.
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