Serum Serotonin Level Can Be Used as a Predictive Marker for Depression in Patients With Type 2 Diabetes Mellitus. True or False?

The possible connection between serum serotonin levels and depression in individuals with type 2 diabetes mellitus (T2DM) has gained considerable interest.By examining HAM-D scores, glycated haemoglobin (HbA1c) levels and serum serotonin in T2DM patients receiving antidiabetic medication, with or without antidepressant treatment, we aimed to assess how medication influences depressive symptoms, considering serum serotonin as a possible marker for depression.Our findings indicate that antidiabetic medication, particularly metformin, contributed to an improvement in depression symptoms, its effects-both antidiabetic and antidepressant-being enhanced when combined with an antidepressant.However, these improvements were not correlated with serum serotonin levels, which showed high variability even within the same group of patients.Consequently, our study does not support the use of serum serotonin as a predictive marker for depression in T2DM patients, as numerous other factors, including metabolic abnormalities, insulin resistance and inflammation, impact both conditions. RezumatPosibila legtur ntre valoarea serotoninei serice i depresie, la persoanele cu diabet zaharat de tip 2, a ctigat un interes considerabil.Prin examinarea scorurilor HAM-D, a nivelurilor de hemoglobin glicat (HbA1c) i a serotoninei serice la pacienii cu T2DM care urmeaz tratament antidiabetic, singur sau n asociere cu antidepresive, ne-am propus s evalum modul n care medicaia influeneaz simptomatologia specific depresiei, lund n considerare serotonina seric ca posibil marker al depresiei.Rezultatele studiului nostru indic faptul c medicamentele antidiabetice, n special metformina, contribuie la ameliorarea simptomelor depresiei, efectele sale -att antidiabetice, ct i antidepresivefiind potenate de medicaia antidepresiv.Cu toate acestea, aceste observaii nu au putut fi corelate cu valorile serotoninei serice, care au prezentat o variabilitate ridicat chiar i n cadrul aceluiai grup de pacieni.n consecin, studiul nostru nu sprijin utilizarea serotoninei serice ca marker predictiv pentru depresie la pacienii cu DZ2, deoarece numeroi ali factori, inclusiv anomalii metabolice, rezistena la insulin i inflamaia, influeneaz ambele patologii.