Key result
Serum serotonin levels were robustly correlated with blood glucose (P=0.008), HbA1c (P=0.007), anxiety (P=0.000), and depression (P=0.000) in patients with type 2 diabetes.
Why the study?
Serotonin levels are important in somatic and psychiatric disorders, suggesting a need to evaluate serotonin levels in patients with comorbid diabetes and anxiety or depression.
Does serum serotonin correlate with anxiety, depression, and glycemic control in patients with type 2 diabetes?
Observational (n=48)
Does serum serotonin correlate with anxiety, depression, and glycemic control in patients with type 2 diabetes?
p-value: p=0.000
Serum serotonin levels significantly correlate with glycemic control, anxiety, and depression in patients with type 2 diabetes, suggesting its potential utility as a screening marker.
May support serotonin screening for glycemia and mood in T2D; observational data leaves open prospective validation before practice change.
Over time, studies have shown the importance of determining serotonin levels to diagnose somatic and psychiatric disorders. There are theoretical premises and practical ways to achieve a subtle correlation between the existence of comorbid psychiatric disorders and somatic diseases caused by the changes observed in serotonin levels. The present study, classified as retrospective and quantitative, provides evidence for determining the serotonin levels in patients with diabetes and anxiety or depression. A total of 48 patients with diabetes type 2 were enrolled in the study. Blood glucose level, glycated haemoglobin, and serum serotonin were noted, and they completed Hamilton A and Beck Depression Inventory questionnaires. We found robust correlations between serum serotonin and blood glucose (Sig. = 0.008), serum serotonin and HbA1c (Sig. = 0.007), serum serotonin and anxiety (Sig. = 0.000), and serum serotonin and depression (Sig. = 0.000). It is also noteworthy that women recorded extreme values higher than men for glycated haemoglobin (95% confidence interval: 6.92-7.79 in women and 6.30-7.23 in men). In conclusion, using serotonin as a marker of the mentioned diseases in clinical practice is of significant utility, considering the benefits in terms of the evolution and prognosis of comorbidities in patients with type 2 diabetes and anxiety and depressive symptoms.
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Moroianu et al. (2022) conducted an observational in Type 2 diabetes with anxiety or depression (n=48). Serum serotonin levels was evaluated on Correlation of serum serotonin with blood glucose, HbA1c, anxiety, and depression (p=0.000). Serum serotonin levels were robustly correlated with blood glucose (P=0.008), HbA1c (P=0.007), anxiety (P=0.000), and depression (P=0.000) in patients with type 2 diabetes.
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