June 1, 2002Anesthesia & Analgesia

An Analysis of Responses to Levosimendan in the Pulmonary Vascular Bed of the Cat

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Why the study?

Does levosimendan reduce lobar arterial pressure in the pulmonary vascular bed of the cat?

Population

Cat model (pulmonary vascular bed under conditions of controlled pulmonary blood flow and constant left…

Comparison

Levosimendan vs Responses after administration of U-37883A…

Design

Preclinical

Authors

BWBracken J. De WittNorth Carolina State University IIIkhlass N. IbrahimLouisiana State University Health Sciences Center New Orleans EBErin Z. BayerTexas Tech University

Discussion

Member takes

Implication

Hypothesis-generating for levosimendan pulmonary vasodilation; leaves open translation to human heart failure therapy.

Structured PICO

Does levosimendan reduce lobar arterial pressure in the pulmonary vascular bed of the cat?

Population

Cat model (pulmonary vascular bed under conditions of controlled pulmonary blood flow and constant left atrial pressure, with lobar arterial pressure increased to a high steady level with the thromboxane A(2) analog U-46619)

Intervention

Levosimendan

Comparator

Responses after administration of U-37883A (ATP-sensitive K+ channel blocker), L-N(5)-(1-iminoethyl)-ornithine (NOS inhibitor), sodium meclofenamate (cyclooxygenase inhibitor), or interrupted lung ventilation

Outcome

Changes in lobar arterial pressuresurrogate

Levosimendan acts as a pulmonary vasodilator in a feline model, partially mediated by ATP-sensitive potassium channels, suggesting an additional mechanism for its efficacy in heart failure.

Cite This Study

Witt et al. (2002) studied this question.

synapsesocial.com/papers/6a781f4bf6b553d308aefd5a https://doi.org/10.1097/00000539-200206000-00009

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An Analysis of Responses to Levosimendan in the Pulmonary Vascular Bed of the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An Analysis of Responses to Levosimendan in the Pulmonary Vascular Bed of the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider