Why the study?
Does intravenous levosimendan improve haemodynamics in a canine model of pacing-induced heart failure with aortic constriction?
Population
18 conscious mongrel dogs.
Comparison
Levosimendan administered intravenously in doses… vs Sham-operated dogs with normal cardiac function…
Design
Preclinical
Authors
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May preferentially boost inotropy in failing hearts; leaves open human translation pending clinical trials.
Does intravenous levosimendan improve haemodynamics in a canine model of pacing-induced heart failure with aortic constriction?
Levosimendan demonstrates potent cardiotonic effects that are significantly more pronounced in failing hearts compared to normal hearts in a canine model.
Udvary et al. (1995) studied this question.
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