Why the study?
Does intracoronary levosimendan improve contractile function in a canine model of stunned myocardium?
Population
Barbiturate-anesthetized dogs subjected to five 5-min LAD occlusions interspersed by 5-min reperfusions to…
Comparison
Intracoronary levosimendan administered via an… vs Control conditions.
Design
Preclinical
Follow-up
10 min equilibration at each dose
Authors
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Preclinical support for intracoronary levosimendan in canine stunning; leaves open translation to human reperfusion injury.
Does intracoronary levosimendan improve contractile function in a canine model of stunned myocardium?
Intracoronary levosimendan dose-dependently improves regional contractile function in a canine model of stunned myocardium with minimal systemic hemodynamic effects.
Jamali et al. (1997) studied this question.
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