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October 1, 2001Journal of Applied Physiology

Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans

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Why the study?

Does muscle metaboreceptor stimulation via posthandgrip muscle ischemia alter baroreflex control of muscle sympathetic nerve activity in healthy subjects?

Population

11 healthy subjects in the supine position

Comparison

2 min of isometric handgrip exercise at 40% of… vs Control conditions

Design

Other

Authors

JCJian CuiElectrophysiologyTWThad E. WilsonUniversity of KentuckyMSManabu ShibasakiSumitomo Electric Industries (United States)

Discussion

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Implication

Supports enhanced baroreflex gain for MSNA during metaboreflex activation in healthy adults; leaves open relevance to cardiovascular disease.

Structured PICO

Does muscle metaboreceptor stimulation via posthandgrip muscle ischemia alter baroreflex control of muscle sympathetic nerve activity in healthy subjects?

P
Population
11 healthy subjects in the supine position
I
Intervention
2 min of isometric handgrip exercise at 40% of maximal voluntary contraction followed by 2.5 min of posthandgrip muscle ischemia, with blood pressure manipulation via intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl
C
Comparator
Control conditions
O
Outcome
Slope of the relationship between muscle sympathetic nerve activity (MSNA) and diastolic blood pressure, and slope of the relationship between heart rate and systolic blood pressuresurrogate

Muscle metaboreceptor stimulation elevates the sensitivity of baroreflex modulation of muscle sympathetic nerve activity, while the sensitivity of baroreflex modulation of heart rate remains unchanged.

Cite This Study

Cui et al. (2001) studied this question.

synapsesocial.com/papers/6a78200da0847c3df1ecc1f9https://doi.org/10.1152/jappl.2001.91.4.1679
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of sympathetic nerve activity during posthandgrip muscle ischemia in humans1994 · 31 citations
  2. 2Human cardiovascular and respiratory responses to graded muscle ischemia1976 · 155 citations
  3. 3Blockade of the pressor response to muscle ischemia by sensory nerve block in man1979 · 71 citations
  4. 4Neurones in the brain stem of the cat excited by vagal afferent fibres from the heart and lungs.1985 · 36 citations
  5. 5Arterial baroreflex buffering of sympathetic activation during exercise-induced elevations in arterial pressure.1990 · 125 citations