Why the study?
Does oral semaglutide affect the bioavailability of the combined oral contraceptive ethinylestradiol/levonorgestrel in healthy post-menopausal females?
Population
25 healthy post-menopausal females
Comparison
Oral semaglutide co-administered with combined… vs Combined oral contraceptive alone for 8 days
Design
Open-label
Follow-up
6 weeks
Authors
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No effect on OC exposure supports coadministration safety; leaves open generalizability to premenopausal users and real-world efficacy.
Does oral semaglutide affect the bioavailability of the combined oral contraceptive ethinylestradiol/levonorgestrel in healthy post-menopausal females?
Oral semaglutide does not affect the pharmacokinetics of the combined oral contraceptive ethinylestradiol/levonorgestrel, indicating no need for contraceptive dose adjustment when co-administered.
Jordy et al. (2018) studied this question.
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