Why the study?
Oral semaglutide may alter the pharmacokinetics of co-administered drugs via the effects of semaglutide or its absorption enhancer, SNAC.
Does oral semaglutide alter the pharmacokinetics of co-administered ethinylestradiol, levonorgestrel, furosemide, and rosuvastatin in healthy subjects?
Population
25 healthy postmenopausal women (Trial 1) and 41 healthy male and female subjects (Trial 2)
Comparison
Co-administration with oral semaglutide vs SNAC alone vs alone
Design
Two separate one-sequence crossover trials
Authors
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Supports no dose adjustment for listed drugs with oral semaglutide; leaves open broader interaction questions pending larger studies.
Does oral semaglutide alter the pharmacokinetics of co-administered ethinylestradiol, levonorgestrel, furosemide, and rosuvastatin in healthy subjects?
Co-administration of oral semaglutide did not clinically meaningfully alter the pharmacokinetics of ethinylestradiol, levonorgestrel, furosemide, or rosuvastatin.
Jordy et al. (2021) studied this question.
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