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August 9, 2026Cellular & Molecular Biology LettersOpen Access

What does ETV4 really do in human diseases: emerging roles, mechanisms, and therapeutic perspectives

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Authors

YSYining SunHWHuimin WangZWZhihan Wu

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Overview

Review explores ETV4's role in various diseases, emphasizing therapeutic targeting for improved outcomes.

Key Points

  • Investigate the multifaceted roles of ETV4 in diseases, focusing on its mechanisms and therapeutic potential.
  • Conceptual synthesis of current research on ETV4 biology
  • Evaluation of ETV4's roles in cancer and nonmalignant contexts
  • Analysis of unresolved challenges and future therapeutic approaches.
  • ETV4 regulates ferroptosis suppression, immune evasion, and metabolic reprogramming.
  • Identified as a transcriptional integrator amid neural, immune, and metabolic signals in malignant environments.
  • Highlight the potential for targeting ETV4 in cancer therapies.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a782d4e2e1896536c840368https://doi.org/10.1186/s11658-026-00949-1
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