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March 14, 2026Neuro-Oncology PediatricsOpen Access

DMG-11. Decoding Ets Transcription Factors Role in Pediatric High-Grade Glioma Heterogeneity

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Authors

AFAntonio C. Fuentes-FayosHPHannah ParkNKNaomi Kobritz

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Overview

Research demonstrates ETV6 affects tumor growth and survival in pediatric gliomas, highlighting its role in gene regulatory networks.

Key Points

  • This research aims to uncover the influence of Ets transcription factors on the biology of pediatric high-grade gliomas.
  • Used a non-invasive postnatal electroporation model for glioma studies
  • Performed comprehensive genomic profiling to identify relevant transcription factors
  • Investigated single-cell data from inducible tumor models to understand gene regulatory interactions
  • ETV6 and other Ets factors are upregulated in pediatric gliomas
  • Disruption of ETV5 inhibited tumor growth and improved survival
  • Revealed interactions between oligodendrocyte progenitor cells and tumor biology

Cite This Study

Fuentes-Fayos et al. (2025) studied this question.

synapsesocial.com/papers/69b4ad8d18185d8a39800fcehttps://doi.org/10.1093/neuped/wuaf001.041
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1OS03.7.A ETS FAMILY TRANSCRIPTION FACTORS ORCHESTRATE CELLULAR HETEROGENEITY IN PEDIATRIC HIGH-GRADE GLIOMAS2025
  2. 2Abstract B046: ETS transcription factors as key modulators of heterogeneity in pediatric high-grade gliomas2026
  3. 3What does ETV4 really do in human diseases: emerging roles, mechanisms, and therapeutic perspectives2026
  4. 4EXTH-92. Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions2025
  5. 5EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas2026 · 1 citations