September 12, 2025Open Access

Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas

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Discussion

Analysis shows endothelin regulates proliferation and proneural-to-mesenchymal transition in gliomas, highlighting the role of the EDNRB receptor.

Endothelin signaling significantly reduces glioma cell proliferation while promoting the proneural-to-mesenchymal transition.
Analysis of patient-derived glioma lines revealed EDNRB as a predominant receptor influencing tumor cell behavior.
Multi-omics and electrophysiological assessments confirmed that endothelins activate pathways associated with increased malignancy.
These results suggest a pivotal role for endothelin signaling in regulating glioma plasticity and aggression.

Pineau et al. (2025) studied this question.

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Analysis shows endothelin regulates proliferation and proneural-to-mesenchymal transition in gliomas, highlighting the role of the EDNRB receptor.