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September 10, 2025Acta Neuropathologica CommunicationsOpen Access

Endothelial transdifferentiation of glioma stem cells: a literature review

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Authors

ABAndrei BuruianăIFIoan Ștefan FlorianIFIoan Alexandru Florian

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Overview

Literature review discusses endothelial transdifferentiation in glioblastoma, suggesting its prognostic relevance.

Key Points

  • Endothelial transdifferentiation of glioma stem cells shows significant heterogeneity in glioblastoma samples, affecting prognosis.
  • GSCs initially form vascular-like channels and express markers like CD31 and CD144, but this eventually diminishes during maturation.
  • The process is influenced by hypoxic environments and the secretome of neighboring cells, activating multiple signaling pathways.
  • GSC-derived endothelial cells integrate with normal endothelial cells, producing a mosaic pattern that may impact treatment responses.

Cite This Study

Buruiană et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce5d54b1d3bfb60f5374https://doi.org/10.1186/s40478-025-02031-x
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