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This is a Animal Study study (also classified as: Quantitative Study).

October 5, 2025Neuro-OncologyOpen Access

Os03.7.a Ets Family Transcription Factors Orchestrate Cellular Heterogeneity in Pediatric High-Grade Gliomas

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Observational analysis reveals key roles of ETS transcription factors in tumor heterogeneity, indicating potential therapeutic targets.

Significant overexpression of ETV5 and ETS factors in pediatric gliomas promotes tumor growth and diversity.
Targeted suppression of ETV5 led to marked reductions in tumor growth and improved survival outcomes in models.
Single-cell analyses demonstrate distinct roles of ETV family members in regulating glioma progression and identity.
ETS factors interact with glial-specific regulators to influence cell differentiation and tumor behavior.

Fuentes-Fayos et al. (2025) studied this question.

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October 5, 2025Neuro-OncologyOpen Access

View Full Paper

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Authors

Observational analysis reveals key roles of ETS transcription factors in tumor heterogeneity, indicating potential therapeutic targets.

Significant overexpression of ETV5 and ETS factors in pediatric gliomas promotes tumor growth and diversity.
Targeted suppression of ETV5 led to marked reductions in tumor growth and improved survival outcomes in models.
Single-cell analyses demonstrate distinct roles of ETV family members in regulating glioma progression and identity.
ETS factors interact with glial-specific regulators to influence cell differentiation and tumor behavior.

Fuentes-Fayos et al. (2025) studied this question.

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