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August 9, 2026Stroke and Vascular NeurologyOpen Access

Cerebral large vessel occlusion stroke multiomics biosample cohort (CLOMB): a multicentre cohort protocol

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Authors

ZFZhiyuan FengMYMing YangJXJing Xue

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Overview

Multicentre cohort study explores biomarkers in acute ischemic stroke with large vessel occlusion, suggesting better treatment paths.

Key Points

  • The study aims to explore localized markers of stroke and futile recanalisation in acute ischaemic stroke patients with large vessel occlusion.
  • Conducting an ambispective cohort study with 500 AIS-LVO patients at five stroke centers in China.
  • Collecting various biosamples including arterial and venous blood, thrombus, and intracranial blood for multi-omics analysis.
  • Performing untargeted metabolomic, proteomic analysis, and single-cell RNA sequencing on a representative subset.
  • The protocol establishes a standard for biosampling and multiomics profiling of patients.
  • It aims to identify biological pathways that could improve stroke outcomes and aid in diagnosis.
  • Follow-up will occur at 3 months and 1 year to assess outcome data.

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/6a782d5f2e1896536c8405e6https://doi.org/10.1136/svn-2025-004729
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Also Consider

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  1. 1ABSTRACT NUMBER: ESOC2026A1711 HISTOPATHOLOGICAL AND PROTEOMIC CHARACTERIZATION OF MECHANICAL THROMBECTOMY RETRIEVED CLOTS IN ACUTE ISCHEMIC STROKE PATIENTS WITH LARGE VESSEL OCCLUSION2026
  2. 2ABSTRACT NUMBER: ESOC2026LB73 LB73 - ENDOVASCULAR TREATMENT FOR MILD ISCHEMIC STROKE WITH ACUTE ANTERIOR CIRCULATION LARGE VESSEL OCCLUSION:A MULTICENTER, PROSPECTIVE, RANDOMIZED, CLINICAL TRIAL (MILD-MT)2026
  3. 3ABSTRACT NUMBER: ESOC2026OT17 PREHOSPITAL BIOMARKER AND PHONE CALL-BASED DETECTION FOR ISCHAEMIC STROKE THROMBECTOMY (PRONTO): WORK IN PROGRESS2026
  4. 4Improving Stroke Outcome Prediction Using Molecular and Machine Learning Approaches in Large Vessel Occlusion2024 · 5 citations
  5. 5Abstract TP293: Acute Ischemic Stroke patients with Large Intracranial Vessel Occlusions who do not undergo mechanical thrombectomy.2026