Cross-sectional study explores how thyroid cysts influence link between antibodies and subclinical hypothyroidism, suggesting a need for further investigation.
Key Points
This study aims to evaluate the role of thyroid cyst status in the relationship between anti-thyroid peroxidase antibodies and subclinical hypothyroidism.
Conducted a cross-sectional study with 1432 euthyroid Japanese participants
Defined thyroid cysts as cystic lesions ≥ 2.0 mm without solid components
Adjusted for confounders like sex, age, and body mass index during analysis.
TPO-Ab positivity was significantly associated with SCH in participants without thyroid cysts (OR 2.10, 95% CI 1.17-3.77)
No significant association was found in participants with thyroid cysts (OR 0.27, 95% CI 0.04-2.02)
Indicates thyroid cyst status may influence the relationship between TPO-Ab positivity and SCH.