Why the study?
Can urine be used as a non-invasive medium to measure proinflammatory cytokines (TNF-alpha and IL-6) in patients with severe congestive heart failure?
Population
60 subjects total: 30 consecutive patients with severe congestive heart failure and 30 matched healthy…
Comparison
Measurement of tumor necrosis factor-alpha and… vs Measurement of TNF-alpha and IL-6 in plasma; and…
Design
Case-control
Authors
Loading...
Urinary cytokine levels match plasma in severe HF; supports non-invasive assessment but leaves open validation before clinical or trial use.
Can urine be used as a non-invasive medium to measure proinflammatory cytokines (TNF-alpha and IL-6) in patients with severe congestive heart failure?
Urinary measurement of TNF-alpha and IL-6 is comparable to plasma measurement, offering a non-invasive method for assessing inflammation in severe heart failure.
Sirera et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: