Demonstrates regioselective hydroxyalkylation in purine derivatives, suggesting a novel synthetic approach.
A linear paired electrolysis strategy enables the highly regioselective C6-hydroxyalkylation of purine derivatives and nucleosides with aldehyde feedstocks in a redox-neutral manner. The reaction involves NHPI-mediated electrocatalytic HAT of aldehydes to generate acyl radicals, which subsequently undergo Minisci-type C–H acylation and cathodic reduction, establishing a practical platform for accessing structurally diverse C6-hydroxyalkylated purine derivatives. A combined divided-cell experiment aided the elucidation of a plausible reaction mechanism.
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Qiao et al. (2026) studied this question.
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