Reveals effective synthesis of benzothiazole derivatives, indicating an efficient method for producing functional compounds.
We established a convenient synthesis of highly functionalized benzothiazole derivatives with thioamides in the presence of acyl halide and sulfoxide at ambient temperature. A series of α‐haloacetophenone‐incorporated benzothiazole derivatives could be constructed in 20%–99% yields through acyl halide/sulfoxide‐based C─X and C─S bond formation. In this process, both AcBr and AcCl can be able to serve as activator of dimethyl sulfoxide (DMSO) and halo source successfully.
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Luo et al. (2026) studied this question.
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