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A convenient synthesis method for the oral anticoagulant rivaroxaban was developed utilizing (S)-epichlorohydrin as the starting material.
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New synthetic route to rivaroxaban and analogs; extends chemical access but leaves open clinical translation.
Rivaroxaban 1 is an oxazolidinone derivative that is the first representative of a new series of anticoagulants,1,2 and it was soon followed by apixaban, betrixaban and darexaban.3–5 It is an oral,...
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Halama et al. (2020) studied this question. A convenient synthesis method for the oral anticoagulant rivaroxaban was developed utilizing (S)-epichlorohydrin as the starting material.
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