Key result
Novel six-step rivaroxaban synthesis achieves 39% overall yield using a Goldberg coupling reaction.
Why the study?
A convenient and facile synthetic route for the production of rivaroxaban was needed.
A novel and convenient synthetic route for the production of the antithrombotic agent rivaroxaban was developed, achieving a 39% overall yield.
Answers are grounded in this paper and cite their sources.
May enable improved rivaroxaban production; leaves open advantages for clinical supply or cost.
A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
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Yuan et al. (2014) studied this question. Rivaroxaban synthesis was evaluated on Overall yield. A novel synthetic route for rivaroxaban was developed, achieving a 39% overall yield over six steps using a Goldberg coupling reaction.
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