What question did this study set out to answer?

To evaluate the timing, course, and potential mechanical or pharmacological causes of acute leukocyte count reductions during early hemodialysis.

March 25, 1968JAMA

Profound neutropenia during the early phase of hemodialysis

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Authors

LKLeonard S. KaplowYale New Haven Hospital

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Implication

Clinical study reveals marked transient neutropenia shortly after initiating hemodialysis, indicating an acute reaction independent of dialyzer filtration or heparin.

Key Points

To evaluate the timing, course, and potential mechanical or pharmacological causes of acute leukocyte count reductions during early hemodialysis.
Monitored circulating total leukocyte and band neutrophil counts during the initial phases of hemodialysis.
Investigated contributing factors including mechanical filtration by the dialyzer, heparin sodium administration, tubing sets, and infusion pump mechanisms.
Patients developed marked, temporary neutropenia 2 to 15 minutes after initiating hemodialysis, followed by an increase in circulating band neutrophils.
Total leukocyte levels returned to near-normal concentrations after approximately one hour, without rebound leukocytosis or pyrogenic symptoms such as fever or chills.

Cite This Study

Leonard S. Kaplow (1968) studied this question.

synapsesocial.com/papers/6a78511f7ecc675f86aeec2d https://doi.org/10.1001/jama.203.13.1135

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Implication

Clinical study reveals marked transient neutropenia shortly after initiating hemodialysis, indicating an acute reaction independent of dialyzer filtration or heparin.

Profound neutropenia during the early phase of hemodialysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Profound neutropenia during the early phase of hemodialysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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