Key result
The WHO criteria for maternal near miss demonstrated a sensitivity of 99.2% and specificity of 86.0% for identifying organ failure compared to the maximum SOFA score.
Why the study?
Do the WHO criteria for maternal near miss accurately predict maternal death and identify organ failure compared to the SOFA score in women with severe maternal morbidity?
Observational (n=673)
No
Do the WHO criteria for maternal near miss accurately predict maternal death and identify organ failure compared to the SOFA score in women with severe maternal morbidity?
The WHO criteria for maternal near miss are highly sensitive for identifying maternal death and organ failure in women with severe maternal morbidity, supporting their use for severity evaluation.
Answers are grounded in this paper and cite their sources.
May support WHO criteria for organ failure identification in severe maternal morbidity; leaves open prospective validation versus SOFA.
BACKGROUND: To evaluate the performance of the WHO criteria for defining maternal near miss and identifying deaths among cases of severe maternal morbidity (SMM) admitted for intensive care. METHOD: Between October 2002 and September 2007, 673 women with SMM were admitted, and among them 18 died. Variables used for the definition of maternal near miss according to WHO criteria and for the SOFA score were retrospectively evaluated. The identification of at least one of the WHO criteria in women who did not die defined the case as a near miss. Organ failure was evaluated through the maximum SOFA score above 2 for each one of the six components of the score, being considered the gold standard for the diagnosis of maternal near miss. The aggregated score (Total Maximum SOFA score) was calculated using the worst result of the maximum SOFA score. Sensitivity, specificity, positive and negative predictive values of these WHO criteria for predicting maternal death and also for identifying cases of organ failure were estimated. RESULTS: The WHO criteria identified 194 cases of maternal near miss and all the 18 deaths. The most prevalent criteria among cases of maternal deaths were the use of vasoactive drug and the use of mechanical ventilation (≥1 h). For the prediction of maternal deaths, sensitivity was 100% and specificity 70.4%. These criteria identified 119 of the 120 cases of organ failure by the maximum SOFA score (Sensitivity 99.2%) among 194 case of maternal near miss (61.34%). There was disagreement in 76 cases, one organ failure without any WHO criteria and 75 cases with no failure but with WHO criteria. The Total Maximum SOFA score had a good performance (area under the curve of 0.897) for prediction of cases of maternal near miss according to the WHO criteria. CONCLUSIONS: The WHO criteria for maternal near miss showed to be able to identify all cases of death and almost all cases of organ failure. Therefore they allow evaluation of the severity of the complication and consequently enable clinicians to build a plan of care or to provide an early transfer for appropriate reference centers.
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Cecatti et al. (2011) conducted an observational in Severe maternal morbidity (n=673). WHO criteria for maternal near miss vs. Maximum SOFA score (gold standard) was evaluated on Identification of organ failure (maximum SOFA score ≥ 3) (Sensitivity 99.2%, 95% CI 94.8-100.0). The WHO criteria for maternal near miss demonstrated a sensitivity of 99.2% and specificity of 86.0% for identifying organ failure compared to the maximum SOFA score.
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