Key result
Systemic lupus erythematosus affects 1 in 1000 women and links to recurrent thrombosis via antiphospholipid antibodies.
Why the study?
The description of a syndrome of recurrent thrombosis, recurrent abortion, and neurological disease associated with antiphospholipid antibodies in systemic lupus erythematosus has provided new insights into the immunological mechanisms, aetiology, and treatment of vascular disease.
Answers are grounded in this paper and cite their sources.
The recognition of antiphospholipid antibodies in systemic lupus erythematosus provides insights into immunological mechanisms underlying recurrent thrombosis and general vascular disease.
Summary: Systemic lupus erythematosus is a common disease- studies throughout the world broadly agree on a prevalence of 1 in 1000 women. Recently an important clinical advance has come from the description of a syndrome of recurrent thrombosis, recurrent abortion and neurological disease associated with antiphospholipid antibodies. The discovery that immunological mechanisms may apply in some cases of thrombosis has led to new insights into the aetiology and treatment of vascular disease in general.
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Graham R.V. Hughes (1973) conducted a review in Systemic lupus erythematosus and antiphospholipid syndrome. Systemic lupus erythematosus affects 1 in 1000 women globally and is linked to a syndrome of recurrent thrombosis, abortion, and neurological disease via antiphospholipid antibodies.
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